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KMID : 0985520120170020056
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Korean Journal of Pancreas and Biliary Tract
2012 Volume.17 No. 2 p.56 ~ p.60
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A Case of Mixed Adenoneuroendocrine Carcinoma in Common Bile Duct
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Baek In-Yub
Chung Yun-Jin
Park Min-Kyu
Jeong Dong-Hyong
Shin Dong-Woo
Kwon Jong-Kyu
Ryu Hyon-Uk
Park Jong-Hoon
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Abstract
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Mixed adenoneuroendocrine carcinoma occurs rarely in the biliary tract. We report a case of mixed adenoneuroendocrine
carcinoma of common bile duct, based on the World Health Organization 2010 classification. A 79-year-old woman complained of right abdominal pain for 2 weeks. ERCP and MRCP revealed a narrow common bile duct with upstream dilatation and biopsy of common bile duct suggested only adenocarcinoma. Pancreaticoduodenectomy was performed, and a tumor was composed of both neuroendocrine carcinoma and adenocarcinoma. Immunohistochemically, neuroendocrine components were reactive for cytokeratin and synaptophysin. The neuroendocrine and exocrine components occurred in separate areas of the same lesion. Liver metastasis was developed at 16 months after surgery. The optimal strategy of management of mixed adenoneuroendocrine carcinoma involving the biliary tract is unknown
because it is very unusual. However, more cases will be helpful to demonstrate clinical course and make a decision about management plans.
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KEYWORD
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common bile duct, mixed adenoneuroendocrine carcinoma
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